I think perhaps the most important problem is that we are trying to understand the fundamental workings of the universe via a language devised for telling one another when the best fruit is. Terry Pratchett on alt.fan.pratchett
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If you follow W3C recommendations regarding colour contrast, you could be actively creating problems for as many as 10% of your site visitors.
It is estimated that as many as 1 in 10 people are dyslexic.
The current population of the UK is around 60.2 million.
National Statistics Online
This implies that the number of dyslexics in the UK is likely to be in the region of 6 million.
If your form email script creates a Reply-To header that doesn’t conform to the examples given in RFC 822, you may find that some of your mails are rejected by SMTP servers - even if your mail headers conform to RFC 2822.